контрактне виробництво
свічки контактне виробництво
виробництво торгова марка
Anuzol
Release form
Rectal suppositories
For children
Not used
For pregnant women
Contraindicated
For nursing mothers
Contraindicated
For drivers
Contraindicated
Storage temperature
to 25 °C
INSTRUCTION
storage
active ingredients: xeroform, thick belladonna extract, zinc sulfate. 1 suppository contains xeroform 100 mg (0.1 g), belladonna extract thick (Belladonnae extractum spissum) calculated on the content of the sum of alkaloids 1.5% 20 mg (0.02 g), zinc sulfate 50 mg (0.05 g) ; excipients: solid fat, glycerin.
Medicinal form
Rectal suppositories. Main physicochemical properties: suppositories of yellow color with a brownish or greenish tint, with the smell of xeroform. The appearance of a barely noticeable white coating on the surface of the suppository is allowed.
Pharmacotherapeutic group
Means for the treatment of hemorrhoids and anal fissures for local use. ATX code C05A X03.
Pharmacological properties
Pharmacodynamics. The properties of Anuzol are due to the effects of the ingredients included in its composition, in particular, antiseptic, astringent, drying, antispasmodic, analgesic, which helps to heal wounds of the mucous membrane of the rectum. Pharmacokinetics. When a suppository is inserted into the rectum, the effect of the drug manifests itself after 15–90 minutes. The duration of resorption of alkaloids ranges from 2 to 6 hours.
Indication
Hemorrhoids, anal fissures in adults.
Contraindication
Increased sensitivity to the components of the drug. Atrial fibrillation, tachycardia, chronic heart failure, coronary heart disease, mitral stenosis, severe arterial hypertension. Acute bleeding. Thyrotoxicosis. Hyperthermic syndrome, diseases of the gastrointestinal tract accompanied by obstruction (achalasia of the esophagus, stenosis of the portal vein, intestinal atony). Angle-closure glaucoma. Liver and kidney failure. Myasthenia gravis. Adenoma of the prostate gland in the stage of decompensation, acute urinary retention.
Interaction with other medicinal products and other forms of interaction
Cardiac arrhythmia occurs when using the drug with monoamine oxidase inhibitors; with quinidine, novocainamide - synergism of the cholinolytic effect is observed; with lily of the valley preparations, with tannin, a physico-chemical interaction is observed, which leads to a mutual weakening of the effects. Anuzol reduces the duration and depth of action of narcotic drugs, weakens the analgesic effect of opiates. With simultaneous use with diphenhydramine or diprazine, the effect of atropine increases; with nitrates, haloperidol, corticosteroids for systemic use - the likelihood of an increase in intraocular pressure increases, with sertraline - the depressive effect of both drugs increases, with spironolactone, minoxidil - the effect of spironolactone and minoxidil decreases, with penicillins - the effect of both drugs increases, with nizatidine - the effect of nizatidine increases, with ketoconazole - the absorption of ketoconazole decreases, with ascorbic acid and attapulgite - the effect of Anuzol decreases, with pilocarpine - the effect of pilocarpine in the treatment of glaucoma decreases, with oxprenolone - the antihypertensive effect of the drug decreases. Under the influence of Octadin, it is possible to reduce the hyposecretory effect of the drug, which weakens the effect of M-cholinemimetics and anticholinesterase agents. With simultaneous use with sulfonamide drugs, the risk of kidney damage increases, with potassium-containing drugs, the formation of intestinal ulcers is possible, with non-steroidal anti-inflammatory drugs, the risk of stomach ulcers and bleeding increases. The effect of Anuzol can be enhanced with the simultaneous use of other drugs with an antimuscarinic effect: M-cholinoblockers, antiparkinsonian drugs (amantadine), antispasmodics, some antihistamines, drugs of the butyrophenone group, phenothiazines, dispyramides, quinidine and tricyclic antidepressants, non-selective inhibitors of neuronal reuptake of monoamines. Suppression of peristalsis under the influence of Anuzol can lead to a change in the absorption of other drugs.
Features of use
Use with caution in patients with prostatic hypertrophy without obstruction of the urinary tract; with Down's disease, with cerebral palsy; with reflux esophagitis; with a hernia of the esophageal opening of the diaphragm, which is combined with reflux esophagitis; with non-specific ulcerative colitis; with megacolon; patients with xerostomia; elderly or debilitated patients; in chronic lung diseases without reversible obstruction; with chronic lung diseases that occur with low production of thick sputum that is difficult to separate, especially in weakened patients; with autonomic (autonomic) neuropathy. Use during pregnancy or breastfeeding. Contraindicated. The ability to influence the speed of reaction when driving vehicles or other mechanisms. Taking into account the possibility of the appearance of such side reactions as dizziness, hallucinations, disturbances of accommodation, during the use of the drug you should refrain from driving vehicles or working with other mechanisms. Method of administration and dosage Apply rectally. Enter into the rectum - 1 suppository 2-3 times a day. The maximum daily dose is 7 suppositories. The duration of use depends on the severity of the disease and the severity of the therapeutic effect. Children. Do not apply.
Methods of application
Apply rectally. Enter into the rectum - 1 suppository 2-3 times a day. The maximum daily dose is 7 suppositories. The duration of use depends on the severity of the disease and the severity of the therapeutic effect. Children. Do not apply.
Overdose
Symptoms: increased manifestations of adverse reactions, nausea, vomiting, decreased blood pressure, excitement, tremors, convulsions, insomnia, drowsiness, hallucinations, irritability, hyperthermia. Suppression of the central nervous system, suppression of the activity of the respiratory and vascular centers, delayed urination, hyperthermia. Treatment. Gastric lavage, parenteral administration of cholinomimetics and anticholinesterase agents. With hyperthermia, wet rubbing and antipyretics are indicated; in case of excitement - intravenous administration of sodium thiopental or sodium oxybutyrate; with mydriasis - locally in the form of phosphacol, physostigmine, pilocarpine eye drops. In the event of a glaucoma attack, immediately instill 2 drops of 1% pilocarpine solution into the conjunctival sac every hour and inject 1 ml of 0.05% proserin solution 3-4 times a day subcutaneously.
Side effects
Gastrointestinal disorders: dry mouth, thirst, taste disturbances, dysphagia, decreased intestinal motility up to atony, decreased tone of biliary tract and gall bladder, constipation, diarrhea. Disorders of the kidneys and urinary tract: difficulty and delay in urination. Cardiac disorders: tachycardia; feeling of heartbeat; arrhythmia; including extrasystole; myocardial ischemia. Vascular disorders: facial flushing, flushing. Neurological disorders: headache, dizziness, nervousness, insomnia. Disturbances from the organs of vision: pupil dilation, photophobia, paralysis of accommodation, increased intraocular pressure, temporary visual disturbances. Disorders of the respiratory system and mediastinal organs: formation of viscous sputum that is difficult to expectorate. Changes on the part of the skin and subcutaneous tissue: skin rashes, urticaria, exfoliative dermatitis. Immune system disorders: anaphylactic reactions, anaphylactic shock. Others: decreased sweating, dry skin, dysarthria, burning in the anus. In the event of the appearance of any undesirable phenomena, it is necessary to consult a doctor.
Expiration date
2 years.
Storage conditions
In the original packaging at a temperature not higher than 25 °C. Keep out of the reach of children.
Packaging
5 suppositories in a strip. 2 strips in a pack.
Leave category
Without a prescription.
Producer
Monfarm PJSC.
Address
Ukraine, 19100, Cherkasy region, Monastyryshche, st. Zavodska, 8.