контрактне виробництво
свічки контактне виробництво
виробництво торгова марка
NOVOCAIN
Release form
Rectal suppositories.
For children
Not used
For pregnant women
Not used
For nursing mothers
Not used
For drivers
Not recommended
Storage temperature
until 15 °C
INSTRUCTION
storage
active substance: procaine; β-diethylaminoethyl ester of paraaminobenzoic acid hydrochloride; 1 suppository contains procaine hydrochloride (novocaine) 0.1 g (100 mg); Excipient: solid fat.
Medicinal form
Rectal suppositories. The main physicochemical properties: suppositories are white or white with a yellowish or creamy shade of color. The presence of a white coating on the surface of the suppository is allowed.
Pharmacotherapeutic group
Means for the treatment of hemorrhoids and anal fissures for local use. Local anesthetics. ATX code C05A D05.
Pharmacological properties
Pharmacodynamics. Disrupts the generation and conduction of nerve impulses, mainly in unmyelinated fibers. Being a weak base, it interacts with receptors of membrane sodium channels, blocks the flow of sodium ions, displaces calcium from receptors located on the inner surface of the membrane. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. The antiarrhythmic effect is associated with an increase in the effective refractory period, a decrease in excitability and automaticity of the myocardium. Eliminates the descending inhibitory effects of the reticular formation of the brain stem. Depresses polysynaptic reflexes. Reduces spasm of the smooth muscles of the intestine. Pharmacokinetics. It is well absorbed after rectal administration. In the process of absorption, it is quickly hydrolyzed, mostly in the bloodstream, with the participation of plasma esterases and cholinesterases, with the formation of para-aminobenzoic acid and diethylaminoethanol. Excreted with urine - 80%.
Indication
Hemorrhoids, anal fissures.
Contraindication
Increased sensitivity to the components of the drug. Arterial hypotension. Myasthenia. Children's age.
Interaction with other medicinal products and other forms of interaction
It should not be prescribed simultaneously with drugs subject to acetylation in the liver (sulfanilamides, hydralazine, isoniazid, procainamide) and hypotensive agents. Simultaneous use with monoamine oxidase (MAO) inhibitors (furazolidone, procarbazine, selegiline) increases the risk of arterial hypotension. The toxicity of procaine is increased by anticholinesterase drugs (they suppress its hydrolysis). Metabolite of procaine (paraaminobenzoic acid) is a competitive antagonist of sulfonamide drugs and can weaken their antimicrobial effect. The drug reduces the effect of anticholinesterase agents on neuromuscular transmission. Cross-sensitization is possible. Potentiates the effect of direct anticoagulants.
Features of use
When using the drug, it is necessary to control the function of the cardiovascular, respiratory and central nervous systems. Due to the possible inhibition of the contractile ability of the myocardium and a decrease in blood pressure, it should be used with great care in case of myocardial infarction. It is not recommended to prescribe with severe atherosclerosis. It should not be prescribed simultaneously with drugs subject to acetylation in the liver (sulfanilamides, hydralazine, isoniazid, procainamide). In the absence of a therapeutic effect within 7 days of using the drug, a proctological examination is required. Use during pregnancy or breastfeeding. The drug should not be used during pregnancy or breastfeeding. The ability to influence the speed of reaction when driving vehicles or other mechanisms. Use with extreme caution when driving vehicles and when working with complex mechanisms, taking into account the possibility of dizziness and weakness.
Methods of application
Enter rectally. Adults - 1 suppository 1-2 times a day. The duration of the treatment course is determined by the doctor individually, taking into account the course and severity of the disease, the achieved therapeutic effect, and general treatment tactics. Children. Do not use the drug for children.
Overdose
When used in high doses, excessive absorption is possible, accompanied by nausea, vomiting, increased nervous excitability, tremors and convulsions, respiratory depression, sudden cardiovascular collapse. Treatment: symptomatic.
Side effects
From the side of the immune system: allergic reactions, possible anaphylactic shock. From the side of the cardiovascular system: arterial hypotension, bradycardia, arrhythmias. From the side of the central nervous system: general weakness, dizziness, headache, drowsiness. From the digestive system: nausea, vomiting. From the side of the blood system: methemoglobinemia. Others: changes in the injection site.
Expiration date
2 years.
Storage conditions
In the original package at a temperature not higher than 15 ºС. Keep out of the reach of children.
Packaging
5 suppositories in strips; 2 strips in a pack.
Leave category
By prescription.
Producer
Monfarm PJSC.
Address
Ukraine, 19161, Cherkasy region, Uman district, village Avramivka, str. Zavodska, 8.